E Human Resource Essay Example | Topics and Well Written Essays - 2500 words

E Human Resource - Essay Example E Human Resource is referred to the management, regulation and use of electronic processes and information relating to human resource and the employment laws. It is an extremely broad term and has been continuously evolving in its field. With the emerging trends like globalization, customer orientation, and specialization, companies have been especially emphasising on recruitments, evolution and sustainment of qualified employees. Companies have gained extensive awareness about the fact that human resources have been gradually transforming from being a cost factor to a success factor. They have also realized that a shrinking population and a shrinking workforce would be the most crucial crisis in the years to come. Many of the activities of the human resource departments can be delegated to the employees using the modern system f information and technology. Electronic Human Resource Management (e-HRM) is a tool which is web based and which helps in automating and supporting the human resource processes. Implementing e-HRM would provide the opportunity to delegate the process of data entry to employees themselves. Moreover it facilitates the use of human resource marketplaces (e-Recruitment) and allows greater amount of self service to employees (Biesalski, n.d., p.1). It is the outcome of the combination of various technologies. Firstly the growing importance of the knowledge factor in organizations has been the driving force behind the evolution of IT. Information systems like e-HRM that provides information allows companies to gain comprehensive and consistent concept for knowledge management. It is important to explain the concept of knowledge management in this regard. Knowledge management is considered to be a collection of various techniques. Using this large variety of techniques, organizations are able to acquire knowledge, organize the knowledge and finally make the knowledge transparent. Intelligent data analysis and e-HRM combined helps to disburden the employees of the human resource

Research Literature Review Breast Cancer in USA Essay Example for Free

Research Literature Review Breast Cancer in USA Essay Introduction Breast cancer continues to be an important focus of attention for medical professionals, policy-makers and general public in the US. The high incidence of the disease and its devastating, in many cases, fatal, outcomes rivet the attention of the professional public. Studies identified for this literature review are for the most part practically oriented, in the sense that they deal with topics that are of primary importance in detecting, treating, and preventing breast cancer. Thus, two sources deal with the programs aimed at women education in the US concerning breast cancer, and two others cover the research into environmental causes of breast cancer. The problem of treatment options for breast cancer is also considered. Education Programs In the US where the population is extremely diverse, creation of special education programs targeting various population groups in accordance with their status is of special importance. Armando Valdez, Kakoli Banerjee, Lynn Ackerson, and Maria Fernandez in their article â€Å"Multimedia breast cancer education intervention for low-income Latinas† outline a special program aimed at the segment of women including Latino women. The problem with detection and early treatment of cancer among Latino women is connected to the fact that Latina women’s screening rate is considerably lower the required government standards and the rate for other ethnic groups. The researchers arrive at the conclusion that, given the availability of subsidized mammograms for poor Latina women, the main deterrent for improvement in the screening rate is lack of knowledge about cancer risks and treatment options. Complicated level of education materials prepared for the target group by the American Cancer Society was identified as an important factor blocking the access of Latina women to adequate information as materials presented often required a superior level of reading skills and the materials were not prepared in Spanish. The paper reports â€Å"the results of a multimedia breast cancer education intervention, tailored to the needs of low-education, low-income Latinas, and attempt to document specific changes in womens knowledge, attitudes and intentions toward mammography screening† (Valdez et al., 2002). Using the Breast Cancer Multimedia Kiosk including instructional videos exposing the target group to the dangers of breast cancer, the authors were able to conclude that interactive multimedia technologies are an effective tool in raising awareness of cancer risks among low-income women. Although the women had some prior knowledge of cancer (â€Å"the majority of baseline study participants (over 80%) knew age and family history as risk factors†), the post-exposure assessment revealed a significant increase in knowledge after the program. Krystal Ngoc-Thy Luong and Jenny K. Yi in â€Å"Apartment-Based Breast Cancer Education Program for Low Income Vietnamese American Women† evaluate a similar program targeting a different ethnic group. As in the case with Latina women, breast cancer is the leading cause of death in this subgroup. Although Asian/Pacific Islander American, or APIA, women have a lower incidence rate of breast cancer (102.0 per 100,000 versus 140.8 per 100,000 for White American women), exposure to Western lifestyle tends to push these rates up. In addition, APIA women tend to be younger when diagnosed with breast cancer than other categories. The study aimed â€Å"to develop, implement, and evaluate the effect of an apartment-based breast cancer educational program for the hard to reach low income Vietnamese women† (Luong, Yi, 2005). The program was designed to be based on apartment visits as it provided a convenient way to reach women, covering neighbourhoods with high concentration of Vietnamese families in Houston. The intervention was carried out by two educators who delivered 20 educational sessions over the period of 3 months that provided the Vietnamese women with information concerning screening, recommendations and referrals to screening. Women were supplied with promotional materials including printed educational information and videos. Measurement of the knowledge levels through telephone surveys concerning breast cancer issues demonstrated that they were â€Å"significantly higher in the intervention group after receiving education about breast cancer when compared to women in the control group† (Luong, Yi, 2005). The researchers drew the conclusion that an apartment-based program has many advantages as compared to other ones because it addresses women in comfortable home settings, giving them a chance to relax and open up more to the conversation with the educator. Environmental Hazards and Breast Cancer Another important direction of research concerns the impact of pollutants and other environmental factors on incidence of breast cancer in women. Thus, Peggy Reynolds, Susan E. Hurley, Robert B. Gunier, Sauda Yerabati, Thu Quach, and Andrew Hertz in â€Å"Residential Proximity to Agricultural Pesticide Use and Incidence of Breast Cancer in California, 1988-1997† evaluate the connection between the facts that California is the most important agricultural state and also demonstrates the highest breast cancer rates in the US. The purpose of the study was formulated as desire to find out â€Å"whether California breast cancer rates were elevated in areas with recent high agricultural pesticide use† (Reynolds et al., 2005). The research was based on the assessment of 176,302 invasive breast cancer cases including â€Å"70,968,598 person-years of observation† (Reynolds et al., 2005). Using Poisson regression analyses, the authors were not able to find a consistent link between living close to the areas of pesticide distribution and having breast cancer. The upshot of the study was that breast cancer was hardly driven by pesticide use, but was more closely related to various social factors such as socioeconomic status. Julia Green Brody and Ruthann A. Rudel in â€Å"Environmental pollutants and breast cancer† address a wider ranger of substances that can lead to breast tumors. The proliferation of breast cancer in North America has caused the need to look for more sources of this disease, examining a wider range of factors. The study covers â€Å"chemicals that may be breast carcinogens, promote growth of breast cells and hormonally sensitive tumors, or affect mammary gland development and susceptibility† (Brody, Rudel, 2003). The researchers identify already known breast cancer risk factors including reproductive factors, exposure to pharmaceutical hormones, diet, ionizing radiation, socioeconomic status and posited the need to identify more factors. Thus, the scholars point to the need to further investigate the risk associated with occupational hazards including exposure â€Å"to the mammary carcinogens benzene, PAHs, and certain organic solvents† (Brody, Rudel, 2003). For instance, speaking of organic solvents, one study identified a connection between breast cancer rates in Danish women and their exposure to these substances in the workplace. The research, after examining 7,802 women with cancer diagnosis, registered a 20-66% rise in breast cancer risk for women who have been employed in occupations that envisaged active exposure to organic solvents. Other studies demonstrated increased risk of breast cancer development for women employed in the chemical industry, textile manufacturing, or nuclear power plants. The authors conclude by saying that more research is needed in the area, but the literature available so far clearly indicates that the link exists between cancer rates and environmental factors. Treatment Options Finally, another issue which has been identified to inspire researchers is the availability of treatment options for cancer and choice between various alternatives. Kathleen B. Donaghy in â€Å"Fostering Sound Medical Treatment Decision Making: A Focusing on Treatment Choices for Breast Cancer† explores this problem. Invoking the decision-making theory, the author evaluates the potential for adequate decision-making in patients struck with this shocking diagnosis. Donaghy (2003) believes that hasty decisions concerning treatment options made on insufficient information are often regretted by the patient later on. As common deterrents that prevent responsible decision-making she identifies five key points: 1.) cognitive overload 2.) failure to fully comprehend treatment options 3.) inability or refusal to process information in the presence of a denial defense 4.) hurried presentation of information by the physician 5.) self-imposed time constraints to get decisions made. (Donaghy, 2003) The article identifies the key strategies that can be employed by the physician to help the patient in the choice, such as providing maximal possible information to guide the patient’s decisions, improving communication, framing information in an appropriate format, obtaining informed consent etc. Using the decision theory to define decision-making as a choice between status quo and other alternatives shed light on patient values that can be involved in decisions regarding breast surgery. Conclusion The pervasiveness of breast cancer in the US makes research related to the issue highly topical. Examination of causes including environmental factors can help craft governmental policies that will prevent the spread of the deadly disease. On the other hand, developing policies aimed at early detection and effective treatment can be instrumental in curbing the death rate from breast cancer. In this light, creation of programs specifically tailored to the needs of individual groups can be an effective solution. Finally, research oriented toward helping the patient make the best decision concerning treatment options will be an important prerequisite of effective treatment programs. References Ackerson, L., Banerjee, K., Fernandez, M., Valdez, A. (2002). A Multimedia Breast Cancer Education Intervention for Low-Income Latinas. Journal of Community Health 27(1), 33+. Retrieved April 14, 2006, from http://www.questia.com/PM.qst?a=od=5000714747 Brody, J.G., Rudel, R.A. (2003). Environmental Pollutants and Breast Cancer. Environmental Health Perspectives 111(8), 1007+. http://www.questia.com/PM.qst?a=od=5002005585 Donaghy, K.B. (2003). Fostering Sound Medical Treatment Decision Making: A Focusing on Treatment Choices for Breast Cancer. Annals of the American Psychotherapy Association 6(4), 6+. Retrieved April 14, 2006, from http://www.questia.com/PM.qst?a=od=5002578878 Gunier, G.M., Hertz, A., Hurley, S.E., Quach, T., Reynolds, P., et al. (2005). Residential Proximity to Agricultural Pesticide Use and Incidence of Breast Cancer in California, 1988-1997. Environmental Health Perspectives 113(8), 993+. Retrieved April 14, 2006, from http://www.questia.com/PM.qst?a=od=5010885312 Ngoc-Thy Luong, K., Yi, J.K. (2005). Apartment-Based Breast Cancer Education Program for Low Income Vietnamese American Women. Journal of Community Health 30(5), 2005, 345+. Retrieved April 14, 2006, from http://www.questia.com/PM.qst?a=od=5011756419

Herbert Spencer Essay -- essays research papers

Herbert Spencer The most extreme reflection of nineteenth-century individualism is to be found in the encyclopedic system of Herbert Spencer (1820-1903). Both his paternal and maternal ancestors were of a long English and French nonconformists, dissenters and rebels, and Spencer traces in his "Autobiography" his "conspicuous disregard" of political, religious, and social authority to the tradition of independence and dissent so long cherished by his family. Spencer’s education was informal, unconventional, and highly deficient in the more traditional studies of literature and history. His father encouraged his interest in the science and tecnology, and Spencer became an engineer. However, he practiced his profession for a few years, because he became increasingly interested in political economy, sociology, biology, and philosophy. He was a subeditor of The economist from 1848 to 1853, and then ventured into a full-time career as a free-lance author. As early as 1842 Spencer contributed to the Nonconformist a series of letters called The Proper Sphere of Government, his first major publication. It contains his political philosophy of extreme individualism and Laissez Faire, which was not much modified in his writings in the following sixty years. Spencer expresses in The Proper Sphere of Government his belief that "everything in nature has its laws," organic as well as inorganic matter. Man is subject to laws bot in his physical and spiritual essence, and "as with man individually, so with man socially." Concerning the evils of society, Spencer postulates a "self-adjusting principle" under which evils rectify themselves, provided that no one interferes with the inherent law of society. In discussing the functions of the state, Spencer is concerned with what the state should not do, rather than what it should do. Maintenance of order and administration of justice are the only two proper realms of government activity, and their purpose is "simply to defend the natural rights of man to protect person and property." The state has no business to promote religion, regulate trade and commerce, encourage colonization, aid the poor, or enforce sanitary laws. Spencer went even so far as to deny the state the right to wage war; but as he says in his Autobiogra... ...yond the ethical sanction bestowed on it by the free consent of the citizens: " The function of Liberalism in the past was that of putting a limit to the powers of the king. The functions of true Liberalism in the future will be that of putting a limit to the powers of parliaments." Spencer’s political ideas hardly changed between 1842, when he published his Proper Sphere of Government, and 1903, the year of his death. The constancy of his political thought in the face of rapidly changing social and economic scene explains why the same ideas that were the last word in radical individualism in the eighteen-forties had become the orthodox conservatism by 1900. And Spencer’s appeal to the English Liberals to return to their original individualism remained unheard, but he correctly foresaw that Conservatives would become the defenders of economic individualism. Spencer failed to see that the issue of the state intervention in the economy was essentially one of means and not of objectives, and that Laissez Faire could be progressive, dynamic, and revolutionary at one time –early 19 century-, and conservative, stagnant, and sterile at another time – late 19 century-.

Escaping an Ever Pressuring Society Essay example -- Essays Papers

Escaping an Ever Pressuring Society James Joyce author of Dubliners, is a book which examines the everyday life of people who live in Dublin. In this intimate portrayal of Dubliners, Joyce writes short stories about the individuals in Irish society. In Dubliners many characters feel the pressure of society, and show their desires to escape. In the stories â€Å"Eveline†, â€Å"Counterparts† and â€Å"The Dead†, the themes of individuals v. society and journey through escape are present. In each story there is a powerful person present that controls a particular person or situation. In Dublin jobs are very important, since they control the social standing in their society. Dublin itself is a major issue to the characters in Dubliners; they wrestle with the ideas of being able to escape. In the story â€Å"Eveline†, a young woman gets the chance to escape from her hard life in Dublin, when a young man named Frank sweeps her off her feet and has plans to move to Buenos Ayres. In â€Å"Counterparts†, a man is faced with the unbearable aspects of his life, when he gets scolded by his boss, humiliated at the pub and when the pressure it too much he takes it out on his son and beats him. â€Å"The Dead† is a story about the realization that even though a couple might be together, they might not necessarily know everything about their significant other. Gabriel gets hit with a realization when he comes to find out that his wife was in love with another man at a young age, and the information is almost disheartening to Gabriel when he hears it. In each of the stories there is a dominant person in their lives. Eveline a young woman struggles with having the responsibility of having to take care of her father a... ...he story is very symbolic to the coldness that is now shared between the couple and the whole town of Dublin, â€Å"his soul swooned slowly as he heard the now falling faintly through the universe and faintly falling, like the descent of their last end, upon all the living and the dead† (225). James Joyce has pointed out many thoughts throughout writing Dubliners. The theme of journeys and escape are present in everyday life living in Dublin, and show how people are unhappy in their current lives and strive to escape through other activities. Reading Joyce he includes many themes that tie into the daily routine of Dubliners. Many references to fire vividly illustrate the point that they live life in a hell. Dubliners is a creative portrayal of individual people living in Dublin, all the while not giving too many facts surrounding a character or story.

Mental Illness: Understanding Depression

Understanding Depression Cassie McFadden General Psychology Understanding Depression Many mental health disorders may affect one’s life to a point of not being able to function. However, one of the most common is depression which is a mental illness causing continuous lethargy, sadness, and even thoughts of suicide. Like many other health conditions, there are several possible symptoms and the disease is not exactly the same in any two people.According to the National Institute of Mental Health common symptoms include, but are not limited to sadness, anxiety, or a hollow feeling, feelings of guilt, irritability, lack of interest or participation in previous hobbies or sex, fatigue, lethargy, increased difficulty remembering or concentrating, insomnia or hypersomnia, eating too little or too much, persistent headaches or body aches. Depression can occur in anyone at any point in their life. â€Å"Most likely, depression is caused by a combination of genetic, biological, enviro nmental, and psychological factors.Depressive illnesses are disorders of the brain. Longstanding theories about depression suggest that important neurotransmitters—chemicals that brain cells use to communicate—are out of balance in depression. But it has been difficult to prove this. † (National Institute of Mental Health, 2012) Although depression is not prejudice and can occur in anyone, women are most commonly affected by the illness. â€Å"Biological, life cycle, hormonal, and psychosocial factors that women experience may be linked to women's higher depression rate.Researchers have shown that hormones directly affect the brain chemistry that controls emotions and mood. † (National Institute of Mental Health) In conclusion, depression is a very serious illness that affects many people every day. Especially for people suffering from chronic or severe depression, it may seem like there is not any hope. However, depression can be managed with proper medic ations which will promote a happier and healthier life. References * National Institute of Mental Health (2012). Depression Retrieved from http://www. nimh. nih. gov/health/publications/depression/what-causes-depression. shtml

Properties and Functions of Money

Properties and Functions of Money Money is an important feature of virtually every economy. Without money, members of a society must rely on the barter system, or some other exchange program, in order to trade goods and services. Unfortunately, the barter system has an important downside in that it requires a double coincidence of wants. In other words, the two parties engaged in a trade must both want what the other is offering. This feature makes the barter system highly inefficient. For example, a plumber looking to feed his family would have to search out a farmer who needs plumbing work done on his house or farm. If such a farmer were not available, the plumber would have to figure out how to trade his services for something that the farmer wanted so that the farmer would be willing to sell food to the plumber. Luckily, money largely solves this problem. What Is Money? In order to understand much of macroeconomics, its crucial to have a clear definition of what money is. In general, people tend to use the term money as a synonym for wealth (e.g. Warren Buffett has a lot of money), but economists are quick to clarify that the two terms are not, in fact, synonymous. In economics, the term money is used specifically to refer to currency, which is, in most cases, not an individuals only source of wealth or assets. In most economies, this currency is in the form of paper bills and metal coins that the government has created, but technically anything can serve as money as long as it possesses three important properties. The Properties and Functions of Money The item serves as a medium of exchange. In order for an item to be considered money, it must be widely accepted as payment for goods and services. In this way, money creates efficiency because it eliminates uncertainty regarding what is going to be accepted as payment by various businesses.The item serves as a unit of account. In order for an item to be considered money, it must be the unit that prices, bank balances, etc. are reported in. Having a consistent unit of account creates efficiency since it would be pretty confusing to have the price of bread quoted as a number of fish, the price of fish quoted in terms of t-shirts, and so on.The item serves as a store of value. In order for an item to be considered money, it has to (to a reasonable degree) hold its purchasing power over time. This feature of money adds to efficiency because it gives producers and consumers flexibility in the timing of purchases and sales, eliminating the need to immediately trade ones income for goods a nd services. As these properties suggest, money was introduced to societies as a means of making economic transactions simpler and more efficient, and it mostly succeeds in that regard. In some situations, items other than officially designated currency have been used as money in various economies. For example, it used to be somewhat common in countries with unstable governments (and also in prisons) to use cigarettes as money, even though there was no official decree that cigarettes served that function. Instead, they became widely accepted as payment for goods and services and prices began to be quoted in the number of cigarettes rather than in official currency. Because cigarettes have a reasonably long shelf life, they do in fact serve the three functions of money. One important distinction between items that are officially designated as money by a government and items that become money by convention or popular decree is that governments will often pass laws stating what citizens can and cannot do with money. For example, it is illegal in the United States to do anything to money that makes the money unable to be further used as money. In contrast, there are no laws against burning cigarettes, aside from those banning smoking in public places of course.

The Search For Identity essays

The Search For Identity essays In her novel, Bastard Out of Carolina, Dorothy Allison tells a story of Bone and the Boatwrights, a family besieged by poverty and violence. Throughout the novel, the reader uncovers the lives of all the different characters, and discovering the identity of these characters plays a large role in understanding the novel as a whole. Within the Boatwright family are women who are constantly faced with the struggle of finding themselves in a patriarchal society. Anney, Alma and Raylene each have their own characteristics and ideals and as the novel progresses, Bone successively displays identity characteristics of each of these women. To Bone, these women exemplify the different levels of independence that a woman can achieve in such a society. In the end, while Alma and Anney are unable to break free from a male-driven society, Raylene remains independent, and Bone finds her own identity through her experiences. Bones aunt, Alma, does not have her own identity- she relies on men and children to form her identity for her. She is married to Wade, a man who consistently has extramarital affairs. Alma had finally caught Wade doing just what hed been doing for years, (83) and moved out with her children, only to break under the stress of not having a man in the household. Alma had sworn she wouldnt have Wade back in her life till he crawled the length of Main Street singing what a dog he was, but when the baby got sick and the boys started running around at night, she gave it up and moved back in with him (90-91). Though Wade blatantly disrespects her in every way, Alma lacks the strength and ability to leave him for good, because doing so would strip her of the only identity that she has possessed for years. After asking Wade to give her another baby, he laughs at Alma, saying that he wouldnt touch [her] even if [she] took a bath in whiskey tonic and put a bag over ...

Inflecting OK

Inflecting OK Inflecting OK Inflecting OK By Maeve Maddox A reader stumbled on the word OKing in the following: Owners of eight rooftop clubs abutting Wrigley Field sued to overturn city approval of the $375 million plan to rebuild the aging ballpark, saying the city broke its own rules in OKing the plan and effectively deprived them of their property rights without due process. After a moment, the reader figured out that OKing was the present participle inflection of OK. NOTE: an inflection is a variation in the spelling of a word to indicate a change in case, gender, number, tense, person, mood, voice, or comparison. OK is inflected as both a noun and a verb. As a noun, OK is used in the plural as well as in the singular. As a verb, it is inflected to show person, number, and tense. A glance at usage in various publications quickly shows disagreement as to how to spell and inflect this indispensable word: Noun: Judge gives her preliminary  OK Is it Okay for My Cat to Have Milk? Get the estimates, then notify the receivers for  their OKs. We soon had inspectors come and give the house all of  their ok’s  and ratings. Verb (Past Tense): Highlights of gun  bill OK’d  by Massachusetts House   Bill delaying plans to move disabled from institutions OKed by NJ Assembly Cyber Bill okayed by US Senate committee; faces uphill struggle Verb (Present Participle): U.S. heading toward OKing more ‘Roundup-Ready’ genetically engineered farm acreage EPA rules on sulfur in gasoline, okaying guns in Indiana school parking lots What help do the authorities offer? The Chicago Manual of Style does not include a rule in any of its numbered sections for spelling or inflecting OK, but it does use the spelling OK in some of its examples. And in its question and answer feature, an editor declares that okay is a standard â€Å"equal variant† of OK. Three of my dictionaries–the OED, Merriam-Webster (M-W), and the Australian Concise Oxford (OA)–show OK as the preferred spelling and okay as an acceptable alternative. My Oxford Canadian Current English (OCC) gives okay as the main entry and OK as an alternative spelling. Here is their take on the inflections of OK as a verb: OED: Present participle OKing or OKing; past tense and past participle OKed, OK-ed, OKed. M-W: OKd or okayed; OKd or okayed; OKing or okaying; OKs or okays OA: OK’s, OK’d, OK’ing OCC: okays or OK’s, okayed or OK’d, okaying or OK’ing Finally, The AP Stylebook does not mess about with alternatives. Here’s the AP rule on inflections for the verb OK: OK, OK’d, OK’ing, OKs. Do not use okay. Bottom line: If you have a stylebook, follow it. If you have a choice, choose the inflected forms that make the most sense to you. Having made your choice, be consistent. Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Style category, check our popular posts, or choose a related post below:10 Rules for Writing Numbers and NumeralsWhat's a Male Mistress?Honorary vs. Honourary

The Effect of Lobbying on Public Opinion Research Paper - 1

The Effect of Lobbying on Public Opinion - Research Paper Example A big extent is the use of the right public relations tools to inform and more crucially, shape opinion. It involves influencing the public process of debates, discussions, and consultations in order to have good or favorable public opinion. In today's modern society, there is widespread use of lobbyists who are either volunteers or some people paid to speak on one's behalf as an advocate. In this regard, part of lobbying is the intent of influencing the legislative process by having favorable laws enacted in relation to a persons or groups special interests. Before a bill becomes a law, drafts are passed around with their justifications and aimed to judge a public reaction (OECD, 2009, p. 160). The public process – lobbyists are required to meet legislators several times. In some cases, lobbying brings about good results as it raises public awareness of certain issues. A good example is recent laws regarding the prevalence and dangers of school bullying which had not been noticed before until some students committed suicides due to bullying. In this instance, the parents are now re-assured their kids are safe at school because of the advocacy or lobbying by a parent of a bullying victim to introduce new laws or to persuade a legislator to vote in a certain way to approve the proposed bill against school bullying (Walston-Dunham, 2008, p. 63). On the other hand, the legislator has gotten a good idea of how public opinion stands on certain issues as relayed to him or her by the lobbyist or advocacy groups.  

Two-Variable Inequality Speech or Presentation Example | Topics and Well Written Essays - 500 words - 1

Two-Variable Inequality - Speech or Presentation Example Write an inequality that limits the possible number of maple rockers of each type that can be made, and graph the inequality in the first quadrant. The; is (0,200) the line slants from the left dropping to right. The line represented is solid. The pertinent segment in the graph is the 1st quadrant. The shaded region is from the line and ends at the origin of the graph. A chain furniture store faxes an order for 175 modern rocking chairs and 125 classic rocking chairs. Will Ozark Furniture be able to fill this order with the current lumber on hand? If yes, how much lumber will they have left? If no, how much more lumber would they need to fill the order? Explain your answers. A graph was obtained by drawing x axis horizontally and y axis vertically. An inequality equation was formed based on the questioned above and thereafter used to draw the graph. The shaded region was identified which then was used to obtain the solutions of the

Industrial Revolution Capitalism and Communism Essay

Industrial Revolution Capitalism and Communism - Essay Example Subsequently, this labor force could not be made to fit itself inside the dimensions of medieval economy that used to be fully controlled by the monarchs, businessmen, and noblemen. Hence, labor organization against the medieval structure of laissez faire led to significant change in industrial and economic relations influencing the society as a whole (Goloboy, 2006). In examining that how the workers’ lives were altered by industrialization, we must say that the workers had to acquire newer skill sets, work for longer, and function production oriented without rest and entertainment. Factory owners chose to exploit them and society changed rapidly. Workers were now underpaid, they lived in factory system, and state became a managing committee of the business owners (Carlton, 1920). Second, mechanization of production processes the number of people working in the factories. The lifestyle in agrarian economy was drastically different from that in the industrial economy. This led to extensive urban development since changes in lifestyle increased ambition and consumption of the masses. After initial hurdles, urban development led to social mixing, abolition of obsolete traditions, and innovation of shorter and simpler social customs, rituals, formalities, etc. But the economic differences between the owners and the workers began to become steeper along with these developments. Owners continued to become richer and workers continued to become poorer. During and after industrial revolution, a new class of businessmen emerged who have enough capital, which they could use to build factories and experiment with different methods production engineering and fund research. This weakened the economic control of monarchs, although no significant political change took place. Hence, a powerful business class – the capitalists emerged, who established the system of capitalism (Goloboy, 2006). Relationship between the working class and the owners was

Bulling in Schools Essay Example | Topics and Well Written Essays - 3250 words

Bulling in Schools - Essay Example This essay approves that the first solution offers the scope that since bullying usually happens in the school premises, teachers will be able to identify any such activity quickly and will be able to educate their students about it. However, teachers cannot be present everywhere all the time and they will not be able to do much about the bullying that happens outside of school premises. The second solution will be of help outside of school premises and since children fear their parents more, they would probably listen to them. However, this does not guarantee that the students will abide by what their parents tell them even in the school premises. The third method is a more direct approach and hence perhaps the best. Educating students directly will help in curbing the activity both within the school premises and outside of it. Though explaining things to students is always a difficult job, however, once the students decide to listen, this method will be the most effective. This report makes a conclusion that the project regarding the problem of bullying in schools was not just an interesting project for me but it also helped me understand the various factors that are associate with bullying. Bullying is a growing nuance in schools and the best solution that can help curb the nuance is to educate people involved in the cycle, the students, parents and teachers. Educating the three will help in complete elimination of the problem. This project helped in developing my knowledge about the problem of bullying and the research helped in increasing my understanding about the various factors associated with the problem. Bullying is certainly a major problem and stern measures need to be taken to curb this nuance.

Compare the way in which institutionalists and Marxists conceive of Essay

Compare the way in which institutionalists and Marxists conceive of the state and its role in the economy - Essay Example By the 1960s, there was ageneral opinion of living in a ‘mixed economy’ (also known as organised capitalism), which changed dramatically since the mid-1970s, when Neo-Liberalism came into existence thataimed atending mixed economy and bringing back market principles unimaginable inthe years just after the WWII.The emergence of Neo-Liberalism in the last few decades has changed the nature of debate on the State’s role, and the state is no longer regarded as a neutral guardian of its citizens, but as a major tool in the hands of the economically powerful social classes or as a predator (Chang, 1994). In this context, the essay will examine the Institutionalists and Marxists notions on the state and its role in the economy, two major theories on political economy that were popularduring the latter half of the twentieth century. The term ‘free market’ generally refers to economy that is free from state intervention. To analyse whether a particular market is free or not, one must review the underlying institutions thatframe the structure for obligations and rights of participants in a specific market,along with various other ‘externalities’ (Schotter, 1985). The institutions that must necessarily be analysed includeregulations(formal and informal ones) that govern the organisation and exercise of interests (regulations on lobbying, political relationshipsand incorporation);ideologiesassociated with concepts of rights and justiceprevalent in that particular society; andthe institutions that ascertainstructural changes in rights and obligations, such as processes for social or legal changes. Therefore, by defining ‘free market’ and ‘state intervention’one can also analyse whether market failure is evident and if state intervention may make the failing market more efficient. From the perspective of the

Bulling in Schools Essay Example | Topics and Well Written Essays - 3250 words

Bulling in Schools - Essay Example This essay approves that the first solution offers the scope that since bullying usually happens in the school premises, teachers will be able to identify any such activity quickly and will be able to educate their students about it. However, teachers cannot be present everywhere all the time and they will not be able to do much about the bullying that happens outside of school premises. The second solution will be of help outside of school premises and since children fear their parents more, they would probably listen to them. However, this does not guarantee that the students will abide by what their parents tell them even in the school premises. The third method is a more direct approach and hence perhaps the best. Educating students directly will help in curbing the activity both within the school premises and outside of it. Though explaining things to students is always a difficult job, however, once the students decide to listen, this method will be the most effective. This report makes a conclusion that the project regarding the problem of bullying in schools was not just an interesting project for me but it also helped me understand the various factors that are associate with bullying. Bullying is a growing nuance in schools and the best solution that can help curb the nuance is to educate people involved in the cycle, the students, parents and teachers. Educating the three will help in complete elimination of the problem. This project helped in developing my knowledge about the problem of bullying and the research helped in increasing my understanding about the various factors associated with the problem. Bullying is certainly a major problem and stern measures need to be taken to curb this nuance.

Absenteeism & Motivation Theories Essay Example | Topics and Well Written Essays - 1750 words

Absenteeism & Motivation Theories - Essay Example employees are not only required to contribute to their level best in their organizations but also required to show loyalty to the place where they earn from, so in order to get maximum from them and in order to utilize their talents at best, motivation is playing a tough role, so that employees keep on moving in the right dimension, they should think and work for their achievements as well as the organization's achievement and they should not give up in life ever.Keeping in view the growing needs of employees there are so many motivational theories that have taken place in the present day organizations, a lot of employees get motivated using such theories, in this discussion we would be discussing few of these theories that are useful for the employees in the given case, the main concerns would be on Douglas McGregor's Theory X and Theory Y, while other useful theory would be Maslow's hierarchy of needs. Both these theories work hand in hand for preventing stress and absenteeism in t he employees of organizations, mostly the stress has been found in financial institutions, yet many other industries have the employee issues. . McGregor's Theory X and Theory Y Theory X The assumption, which says that employees who dislike work are lazy, they dislike responsibility, and they must be coerced to perform well. This should be relatively more discussed in this case because either way the organization should be concerned with taking out work from the employees but it could be so wonderful if employees do not need any such dose and they somehow get shifted to Theory Y. Theory Y The assumption, which says that employees who love their work are creative, they seek responsibility and they can exercise self-direction. The organizations should try to bring their employees under this theory naturally and this is what we would be discussing. Douglas McGregor gave two different views of human beings, the first view is the negative view and is known as theory X, the other view is positive and is known as theory Y, the entire explanation of the theory says that the manager shows his or her behavior according to certain assumptions, the theory X would be the effective one here, as the employees are assumed to be forced to work, the four basic assumptions for theory X are, 1. Employees inherently dislike work and whenever possible, will attempt to avoid it. 2. Since employees dislike work, they must be coerced, controlled, or threatened with, punishment to achieve goals. 3. Employee will avoid responsibilities and seek formal direction whenever possible. 4. Most workers place security above all other factors associated with work and will display little ambition.Now lets have a look at the assumptions of theory Y that is not applicable in this case because of the fact that employees are not hardworking and not devoted to their work. But the organization has to bring them in this category. 1. Employees can view work as being as natural as rest or play. 2. People will exercise self-direction and self-control if they are committed to the objectives. 3. The average person can learn to accept, even seek, responsibility. 4. The ability to make innovative decisions is widely dispersed through out the population and is not necessarily the sole province

HIV (Human Immunodeficiency Virus) Essay Example for Free

HIV (Human Immunodeficiency Virus) Essay HIV (Human Immunodeficiency Virus) causes AIDS (Acquired Immune Deficiency Syndrome) that disables the immune system.  It was discovered in 1983 .HIV enters the body through the bloodstream and duplicates itself rapidly.  The victim is susceptible to infectious diseases that eventually are fatal (1). Statistically, HIV/AIDS is the number one killer of African-American women ages 25 to 34, according to the Centers for Disease Control and Prevention.  Between 2000 and 2003, they were nineteen times more likely than White females and five times more likely than Hispanic females to contract the disease.   African-American men were seven times more likely than White men and three times the rate of Hispanic men to contract HIV/AIDS (2). In 2008, there is still not a cure for AIDS.  Instead, scientists have discovered drugs that can slow down the progression of the disease. Protease inhibitors (PIs) are antiviral drugs that slow down the spread of HIV (1). The virus produces a protein called protease so that it can replicate itself.  Ã¢â‚¬Å"Protease cuts long chains of proteins and enzymes into shorter chains, the first step in the process by which HIV infects a cell† (1).  If this doesn’t happen, replication does not continue. In 1987, AZT was the first anti-HIV medication that was created.   It showed hope and kept people healthier longer.   However, the side effects were very high for men.   Since that time, more HIV medications have evolved.   Antiretroviral therapy usually consists of combinations of nucleoside/nucleotide reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, protease inhibitors, or fusion inhibitors, which are prescribed in the later stages of HIV (19). Dual protease inhibitor therapy is also being used clinically (3).  They are also associated with improving morbidity and mortality of HIV-positive persons (5).  Although these drugs are expensive, they have proven to be the most successful therapy in managing HIV.   However, some patients don’t comply 100% with their treatments.   This is largely due to the side effects. Sometimes they make a patient feel worse than the actual disease. The most commonly reported ones are abdominal pain, abnormal bowel movements, diarrhea, fatigue, headache, and nausea.   Children usually develop a skin rash. The more serious side effects are liver problems and pancreatitis.   Some patients have also seen large increase in triglyceride ad cholesterol levels.   Diabetics saw an increase in their blood sugar levels.   Other patients developed diabetes while taking protease inhibitors (16). Presently, nine PIs have been approved for use in the United States and Europe:   amprenavir, atazanavir, fosamprenavir, lopinavir, indinavir, ritonavir, saquinavir, tipranavir, and nelfinavir. Three non-nucleoside reverse transcriptase inhibitors (NNRTIs) are used for treatment of HIV:  nevirapine, delavirdine, and efavirenz (7). Drug treatment selection depends on factors such as drug resistance, tolerability, drug interactions, and effectiveness. Therapeutic drug monitoring (TDM) â€Å"has been proposed so that practitioners may better maintain appropriate plasma concentrations of drugs in their patients by identifying interactions with other medications and assessing medication adherence   (7). Figure 1 shows the structures of these compounds. Fig. 1. Chemical structures of protease inhibitors and non-nucleoside reverse transcriptase inhibitors. About 50% of â€Å"treatment-naà ¯ve patients† don’t have continued antiviral response after one year of therapy (18). In some cases, there is a development of drug resistance and metabolic complications.   Also, â€Å"there is increasing evidence that virological treatment failure is correlated with variations in the pharmacokinetic parameters of drugs (20).   This can be due to drug interactions, low bioavailability, and variations in metabolic enzyme activity.   Atazanavir (ATV) has good oral bioavailability and a favorable pharmacokinetics profile (18).   With this in mind, patients can mostly take a once-daily dose. A separate analytical method has been recently published for quantifying ATV in human plasma using solid phase extraction and HPLC with PDA (photodiode array) detection at 201 nm (18).   This method provides excellent separation of ATV from its internal standard, clozapine (CLZ) and the other PIs, thus, obtaining an accurate measurement of the drug (see figure 2). CLZ elutes at 8.9 minutes, and ATV elutes a 24.4 minutes. A 40-ml injection resulted in a recovery yield of 100%. Fig. 2.   Chromatogram of ATV with PIs/NNRTIs (8000 ng/ml) spiked with CLZ Nelfinavir mesylate has been shown in phase III controlled clinical trials to significantly reduce viral load and increase CD4+ cell counts when used with reverse transcriptase inhibitors. It’s prescribed as part of triple drug combination therapy (9). CD4+ are helper T cells.   They are important for immune reconstitution in patients that are receiving antiretroviral therapy (10).   After a large number of these cells are destroyed, AIDS develops (7). Six clinical trials was conducted in the past ten years using 2, 148 HIV-infected children enrolled in the Pediatric AIDS Clinical Trials Group treatment trials (10).   Patient ages varied from 2 to 7 years of age.   The focus was to observe short-term variability of CD4 percentages.   The study found that 49% of patients had CD4 percentages above 25%.   32% of patients had CD4 counts between 15% and 24%; 19% were less than 15%.   Finally, 5.4% had a CD4% of less than 5% (10). In June 2006, Darunavir (DRV) was licensed in the United States.   It is a promising PI that is active against HIV strains that are resistant to the other PIs that currently on the market (17).   It is prescribed in 600-mg doses that are taken twice daily with 100 mg of ritonavir that acts as a booster. Protease inhibitors are associated with unfavorable pharmacokinetics and many side effects such as gastrointestinal disturbances and lipid abnormalities (5).  Four of the most common PIs used are indinavir, ritonavir, saquinavir, and nelfinavir (3).  Ã¢â‚¬Å"Monitoring blood concentration of PIs, which can indicate both therapeutic and toxic levels of the drugs as well as patient noncompliance with the medication, may improve the care of both HIV-infected adults and children† (3). When ritonavir was first introduced, it was given in doses of 600 mg every 12 hours. â€Å"However, patient intolerance of full doses led to its primary use as a pharmacologic enhancer to increase the concentrations in plasma of a second protease inhibitor to improve the convenience of antiretroviral regimens by extending the dosing interval, reducing pill burden, and /or eliminating food-induced reductions in pharmacokinetic exposure† (8).   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Researchers used High Performance Liquid Chromatography (HPLC) to determine concentrations of PIs in blood.  Various methods have been used to study the pharmacokinetics and drug interactions. Interpreting plasma levels can be used to â€Å"individualize drug dosage of antiretrovirals (4). Quality control (QC) procedures must be done to ensure that these methods are accurate and precise.  Ã¢â‚¬Å"Such procedures usually include intralaboratory (internal) method validation, intralaboratory QC procedures, and participation in an interlaboratory QC program for antiretroviral drugs† (4). Since the latter hadn’t been done before, it was established so that laboratories can obtain better measurement results of antiretroviral drugs. Nine laboratories participated in the first part of the program.  The first part of the experiment involved the measurement of the protease inhibitors:  indinavir, nelfinavir, ritonavir, and saquinavir.  All had a specified purity of 99% or higher.  QC samples were prepared by spiking blank plasma from HIV-negative volunteers with PI standard. The low concentrated standards ranged from 0.087 to 0.15 mg/L while the intermediate concentrated standards contained ranged from 2 to 3 mg/L of all four PIs.  Finally, the high-concentrated standards contained approximately 5 to 11 mg/L of drug.  All drugs were dissolved in methanol following accurate weighings and diluted with blank plasma (4). High Performance Liquid Chromatography (HPLC) was used to analyze twelve samples.  All laboratories measuring more than one protease inhibitor used as assay for â€Å"simultaneous determination† (4).  Six laboratories used HPLC/UV and three labs used HPLC-MS/MS. Mass spectrometry detection is often recommended for measurement of low concentration levels.  Also, this type of analysis is usually faster and â€Å"does not require complete resolution of drugs for detection and quantification† (5).  Only five laboratories were able to measure all four PIs.  Three laboratories were not able to determine nelfinavir.  One laboratory only measured indinavir (4). Acceptable accuracy results are between 80% and 120%.  Only indinavir resulted in an acceptable accuracy of 80%.  The remaining PIs had between 36% and 74% accuracy.  These results should encourage laboratories to improve their analytical methods and QC procedures.  Other PIs, such as amprenavir and lopinavir, can be analyzed as well (4). HIV-positive plasma samples are heat inactivated before analysis, approximately 58 °C for 40 minutes, to decrease the risk of infection to the operator.  They may also go through a freeze/thaw cycle. As with the QC study, blank plasma was spiked with seven PIs (indinavir, amprenavir, atazanavir, ritonavir, saquinavir, lopinavir, and nelfnavir) at low, intermediate, and high concentrations measured in ng/ml.  Certain assays only require 100  µl of plasma for analysis.  Ã¢â‚¬Å"This is advantageous when measuring PI concentrations as part of clinical studies as they often necessitate hourly sampling to generate complete PK profiles; therefore less blood can be drawn from the patient† (5).  In addition, seven PIs can be quantified in one assay, but impossible to assay all seven in a single preparation. â€Å"The use of liquid chromatography coupled to tandem mass spectrometry (LC-MS-MS) has emerged as the developmental method of choice supporting clinical and pre-clinical pharmacokinetic studies† (13). Recovery for the HPLC-MS/MS methods was above 87% for all seven drugs at all three concentration levels (5).  It was successful in quantifying seven PI concentrations in plasma of HIV positive persons that participated in a run time of nine minutes.  Therefore, the assay may be used for determining PI concentrations in semen, lymphocytes, and cerebrospinal fluid (5). A fast and highly-sensitive LC-MS-MS method was developed that could analyze five protease inhibitors (amprenavir, indinavir, nelfinavir, ritonavir, and saquinavir) in one run using an internal standard.   Sample sizes were small (ng/ml) and run times were approximately 5 minutes.   Recoveries for all five PIs were between 87% and 92%(11). Tipranavir is part of a class of non-peptidic PIs that works against both â€Å"wild-type virus and variants resistant to current PIs†(6).  It also has a high genetic barrier.  Tipranavir is prescribed in a 500-mg dose taken in combination with 200 mg of ritonavir twice daily as part of antiretroviral therapy for patients with HIV-1 strains that are resistant to multiple PIs (6). Fig. 3. Tipranavir chemical structure   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  An HPLC-UV method has been validated and is currently applied when monitoring tipranavir (TPV) plasma levels in HIV patients.  Samples were prepared for solid phase extraction (SPE) by conditioning the cartridges with 0.1% phosphoric acid, pH 7.  TPV stock solutions with a concentration of 5 mg/ml were diluted from with 50% methanol. Samples were spiked with TPV at 1.875, 7.5, 18.75, 37.5, 60, and 75  µg/ml in triplicate. QC samples were diluted with blank plasma and phosphate buffer to 5.625, 22.5, and 67.5  µg/ml.  Clozapine was used as the internal standard (6).  5-ml aliquots of blood samples were obtained from HIV infected patients.  The plasma obtained from centrifugation was heated at 60 ° C for one hour in a water bath. TPV in plasma was measured at a UV absorbance of 201 nm with a retention time of 32.2 minutes. Its internal standard, clozapine (CLZ) has a retention time of 8.3 minutes (6). Figure 4 below shows the chromatogram of TPV, its internal standard, and all other PIs and NNRTIs  present.   Figure 5 shows TPV and its internal standard CLZ only. Fig. 4. Chromatogram of plasma control sample of TVP (22.5 mg/ml) spiked with internal standard and all PIs and NNRTIs. Fig. 5. Chromatogram of calibration sample of TVP (37.5 mg/ml) spiked with internal standard CLZ. Isocratic HPLC methods combined with the use of UV and fluorescence detection produces more sensitivity. Amprenavir is a fluorescent compound.   Its internal standard PR25 can also be seen under fluorescence (see figure 6). Fig. 6.   Blank plasma with 100 ng/ml amprenavir and 1000 ng/ml of PR25 seen under fluorescence. In conclusion, much progress has been made in the development of protease inhibitors and other antiretroviral therapy. HPLC with UV detection has been the most commonly used method of analysis.   It is rapid, simple, and highly sensitive.   LC-MS-MS has been noted at the developmental method of choice for clinical and pre-clinical pharmacokinetic studies (13).   More compounds can be analyzed in less time.   Also, they can be used for methods using other human biological matrices. For the majority of protease inhibitors, all side effects are not known. In 2007, darunavir was the new HIV protease inhibitor with eleven other antiretroviral agents on the market.   They can affect patients that have diabetes, liver problems, and hemophilia; their conditions can worsen as a result of taking PIs. Only a patient’s health care provider can determine the best treatment option REFERENCES Nagel, Rob. 2007. Protease Inhibitors. UXL Encyclopedia of Science; [cited 2008 May 8], Available from http://galenet.galegroup.com/servlet/SciRC?ste=1docnum=cv2644301082. Health Hotline:   HIV and Genital Herpes [cited 2008 May8]; Available from http://www.ebony.com. â€Å"HPLC Assay for Common Protease Inhibitors Developed.†Antiviral Weekly; [cited 2008 May 07; Available from http://galenet.galegroup.com/servlet/SciRC?ste=1docNum=A60069570. Aarnoutse, Rob E., Verweij-van Wissen, Corrien P.W.G.M., van Ewijk-Beneken Kolmer, Eleonora, W.J., Wuis, Eveline, W., Koopmans, Peter P., Hekster, Yechiel A., and Burger, David, M. 2001. International Interlaboratory Quality Control Program for Measurement of Antiretroviral Drugs in Plasma; Antimicrobial Agents and Chemo 46(3): 884-886. Dickinson, Laura, Robinson, Lesley, Tjia, John, Khoo, and Saye, Back, David. 2005. Simultaneous determination of HIV protease inhibitors amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir in human plasma by high-performance liquid chromatography-tandem mass spectrometry; J of Chrom. B 829:82-90. Colombo, S., Beguin, A., Marzolini, C., Telenti, A., Biollaz, J., and Decosterd, L.A. 2006.   Determination of the novel non-peptidic HIV-protease inhibitor tipranavir by HPLC-UV after solid-phase extraction; J of Chrom. B 832:138-143. Rezk, Naser L., Tidwell, Richard R., and Kashuba, Angela D.M. 2004.   High-performance liquid chromatography assay for the quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in human plasma; J of Chrom. B 805:241-247. Shelton, Mark J.,Hewitt, Ross G., Adams, John, Dela-Coletta, Andrew, Cox, Steven, and Morse, Gene D. 2003. Pharmacokinetics of Ritonavir and Delavirdine in Human Immunodeficiency Virus-Infected Patients; Antimicrobial Agents and Chemo 47(5): 1694-1699. Zhang, Kanyin E., Wu, Ellen, Patick, Amy K., Kerr, Bradley, Zorbas, Mark, Lankford, Angela, Kobayashi, Takuo, Maeda, Yuki, Shetty, Bhasker, and Webber, Stephanie. 2001.Circulating Metabolites of the Human Immunodeficiency Virus protease Inhibitor Nelfinavir in Humans:   Structural Identification, Levels in Plasma, and Antiviral Activities; Antimicrobial Agents and Chemo 45(4): 1086-1093. Carey, Vincent J., Pahwa, Savita, and Weinberg, Adriana. 2005.   Reliability of CD4 Quantitation in Human Immunodeficiency Virus-Positive Children:   Implications for Definition of Immunologic Response to Highly Active Antiretroviral Therapy; Clinical and Diagnostic Lab Immunology 12(5): 640-643. Chi, Jingduan, Jayewardene, Anura L., Stone, Judith A., Motoya, Toshiro, and Aweeka, Francesca. 2002.   Simultaneous determination of five HIV protease inhibitors nelfinavir, indinavir, ritonavir, saquinavir and amprenavir in human plasma by LC/MS/MS; J of Pharm and Biomedical Analysis 30:675-684. Verbesselt, R., Van Wijngaerden, E., and de Hoon, J. 2007. Simultaneous determination of 8 HIV protease inhibitors in human plasma by isocratic high-performance liquid chromatography with combined use of UV and fluorescence detection: Amprenavir, indinavir, atazanavir, ritonavir, lopinavir, saquinavir, nelfinavir and M8-nelfinavir metabolite; J of Chrom. B 845:51-60. Frerichs, Valerie A., DiFrancesco, Robin, and Morse, Gene D. 2003. Determination of protease inhibitors using liquid chromatography-tandem mass spectrometry; J of Chrom, B 787:393-403. Gangl, Eric, Utkin, Ilya, Gerber, Nicholas, and Vouros, Paul. 2002. Structural elucidation of metabolites of ritonavir and indinavir by liquid chromatography-mass spectrometry; J. of Chrom. A 974:91-101. Turner, Michele L., Reed-Walker, Kedria, King, Jennifer R., and Acosta, Edward P. 2003. Simultaneous determination of nine antiretroviral compounds in human plasma using liquid chromatography; J. of Chrom. B 784:331-341. 2008. Kaletra. [Cited 2008 May 16], Available from http://www.heartandsoul.com. D’Avolio, Antonio, Siccardi, Marco, Sciandra, Mauro, Lorena, Baietto, Bonora, Stefano, Trentini, Laura, and Di Perri, Giovanni.2007. HPLC-MS method for the simultaneous quantification of the new HIV protease inhibitor darunavir, and 11 other antiretroviral agents in plasma of HIV-infected patients; J. of Chrom. B 859:234-240. Colombo, S., Guignard, N., Marzolini, C., Telenti, A., Biollaz, J., and Decosterd, L.A. 2004. Determination of the new HIV-protease inhibitor atazanavir by liquid chromatography after solid-phase extraction; J. of Chrom. B 810:25-34. Weller, Dennis R., Brundage, Richard C., Balfour, Jr., Henry H., and Vezina, Heather E. An isocratic liquid chromatography method for determining HIV non-nucleoside reverse transcriptase inhibitor and protease inhibitor concentrations in human plasma; J. of Chrom. B 848:369-373. Sarasa-Nacenta, Maria, Lopez-Pua, Yolanda, Mallolas, Josep, Blanco, Jose’ Luis, Gatell, Jose’ M., and Carne’, Xavier. Simultaneous determination of the HIV-protease inhibitors indinavir, amprenavir, ritonavir, saquinavir and nelfinavir in human plasma by reversed-phase high- performance liquid chromatography; J, of Chrom. B 757:325-332.

Dells Business Model Revenue Model Information Technology Essay

Dells Business Model Revenue Model Information Technology Essay Michael Dell, a student from university of Texas, Austin founded Dell Computers. At first Dell sold upgrades for IBM compatible PCs and then in 1985 they started to sell its own brand of PCs. Dell operated on the direct sales model, taking orders over the phone and building PCs to the customers specifications. Dell entered the retail PC channel for several years in the early 1990s, but a downturn in business in 1993 led it to return to its roots as a direct vendor (although the company does work with resellers in some markets). Dell grew rapidly and in the mid-1990s, its sales reached an inflection point, soaring from $3.5 billion in 1994 to $25 billion in 1999. By 1999, Dell had become the number one PC seller in the United States, and was number two worldwide. This success has taken place against the backdrop of falling PC prices, brutal competition, and enormous losses by other PC makers. Dell has not only survived, but succeeded in this environment thanks to the fundamental advantages of the direct model, and to its continued efforts to improve its execution of that model. It also has taken advantage of its direct model to build strong, stable relationships with the large corporations and other organizations who are its core customers. Unlike indirect vendors, Dell knows who its customers are and has a great deal of information that it uses to provide a high level of service and support, to target customers for retention and expanded sales, and to sell additional third party hardware and software. But even Dell has not been immune to the turmoil in the PC industry. While its most recent 26% growth rate continues to outpace the industry as a whole, it has not been able to match its earlier growth rates of 50% a year, and was hit hard by t he slowdown in PC sales in late 2000. The result has been a sharp fall in Dells stock price and a reminder that Dell is vulnerable to the brutal price competition and cyclical demand of the PC industry. Nature of products/services In making an examination of the corporate information relating to the Dell Inc company, it is apparent that the Groups principal activity is said to relate towards the designing, developing, manufacturing, marketing, selling and supporting a very vast range of computer systems. Dell is said to operates within four main segments and these are large enterprise, public, small and medium business and consumer segments. Essentially, large enterprise customers are said to include large global as well as national corporate businesses. Among the public customers of Dell include educational institutions, government, health care, and also law enforcement agencies. What is noted here is that small and medium business focuses on providing small and medium-sized businesses with what is said to be the simplest and most complete standards-based IT solutions and also services, that are customized in order to meet their needs. It is apparent that consumer business sells to customers via Dells on-line store, over the phone, and also through retail. Dell is said to offers a wide range of product categories and these including servers, mobility products, software and peripherals, desktop PCs, networking as well as storage (Corporate Information.com Dell Company, 2010). Dells Business Model/Revenue Model A busines model taxonomy like that of Dell is capable of being utilized to identify competitors and is needed to provide a good understanding of their target-market and this is especially in electronic and computing business competitors which can change very fast. The business model is said to be the term used to describe the way that Dell does business and the revenue model is said to lay out the process by which Dell makes money by specifying how it is going to charge in relation to the services provided (1000 Ventures.com Business Models, 2010) It is submitted that six main components of a business model like is used by Dell and these include the following: Value Proposition this is a description of the problem relating to the customer and the solution that addresses the problem as well as the value of this solution in relation to the customers perspective. Market Segment This relates to the group to target, to recognize that different market segments tend to have different needs and there are chances of innovation to be unlocked when a different market segment is targeted. Value Chain Structure This relates to the position and activities of Dell in the value chain and the way that it captures a part of the value which it is said to creates in the chain. Revenue Generation and Margins This relates to the way that revenue is generated, the cost structure, and also the target profit margins. Position in the Value Network This relates to the identification of competitors, complementors, and any sort of network effects which can be utilized by Dell so as to be able to be utilized to deliver more value for Dell customer. Competitive Strategy This relates to the way that Dell attempts to develop a sustainable competitive advantage and to utilize this to improve Dells competitive position in the market. How Does Dell Use E-Commerce to Improve Supply Chain When internet technology arrived, Dell was quick to set up the ecommerce Processes that would enable it to also sell directly online to customers. Selling online allows the whole process to be automated and more efficient. Since 1996 when Dell opened its website www.dell.com for ecommerce, the company has had huge sales success. By 1997 the company recorded $1 million in online sales. By 2000 the companys internet sales had reached $50 Million a day! If we go back to our example above, the customer, Liam, would go to Dells Irish website www.dell.ie to buy his notebook computer. The full Product range is online with detailed information to help him make his decision. He simply follows the easy, automatic instructions that come up on screen. These allow him to customise the computer he wants with the features he needs. He can increase, say, his hard disk space and see the difference that increase makes to the overall price. Then he is given a variety of options on how to pay, either directly online or, via a customer service operator. There is even an automated leasing option available through a financing arrangement that Dell has here with Permanent TSB. Liams order is then passed automatically through to the production department at Dells factory in Limerick where it will be manufactured to his specification, tested and shipped out to him. All of the systems relating to the sale are done through e-commerce: order placement, order tracking, payment processing, inspection, testing and delivery. Similarly, internally at Dell, the whole purchase and procurement of materials is automated between Dell and its suppliers. At www.valuechain.dell.com, Dell shares information with its suppliers on a range of topics, in cluding product quality and inventory. The crucial benefit is the total automation of the whole process, which not Only makes it faster and more efficient, but also much more cost effective, Especially given the volume of business involved. Dells global website Receives more than 1 billion page requests per quarter at 80 country sites in 28 languages and 26 currencies. Dells approach to e-commerce simulates the benefits of face-to-face contact between the buyer and the seller. This ensures that staff can be focused on delivering a quality product and providing excellent customer service and support How Dells E-Commerce Focus Improves Customer Service Dell has created many features and services online to help the customer see the whole purchasing process clearly. The premise of Dells business is selling directly to customers customers tell Dell exactly what they want and Dell provides them with the goods directly. As well as being able to customise the product, customers can track the progress of the order as it is produced and delivered. This can help the customer see the stages of the process and likely delivery times. Customers can create and view their service records online. This includes product support, shipment and delivery dates. Each purchase comes with a service tag code, which can track the model bought and its service requirements. This allows Dell customer service representatives to quickly and efficiently handle requests. This level of 24 hour customer service and fast response time helps Dell build strong customer relations, which of course is crucial for the company in its understanding of customer needs. It is a lso a very cost-effective way of providing sales and support cost savings which can be passed on in the form of better prices to customers. Success depends greatly on the efficient management of the website. The customer must have a convenient experience when shopping online and have faith that Dell will successfully complete the order and safeguard financial details. Customers need to be comfortable using paperless transactions without face-to-face contact. It is crucial that customers consider purchasing online as an alternative to the traditional method of going into a retailer and buying a product off-the-shelf. Dell is focussed on enhancing its image and relationships, not only with customers, but also with employees and the wider community. To do this, the website is also used as a communication tool for news, press releases and general information to help customers, employees, the media and prospective employees find out more about the company. Limitations of E-commerce to the business (DELL) Technological Lack of universally accepted standards for quality, security, and reliability Telecommunication bandwidth is insufficient (mostly for m-commerce) Software development tools are still evolving. Difficulties in integrating the internet and EC software applications and databases. Special web servers are needed in addition to the network servers (added cost) Internet accessibility is still expensive and/ or inconvenient Order of fulfillment of large-scale B2C requires special automated warehouses Non-technological Security and privacy concerns deter some customer from buying Lack of trust in EC among consumers Many legal and public policy issues, including taxations, remain unresolved National and international government regulations sometimes get in the way Difficulty in measuring some benefits in EC. (e.g. advertising,) lack of matured measurement methodology Some customers like to touch and feel the product Adamant to change from physical to virtual store Lack of trust in paperless, faceless transactions Insufficient number (critical mass) of sellers and buyers (some cases) needed to make profit Increasing number of fraud on the net Difficulty to obtain venture capital due to the dot-com disaster Limitations of E-commerce to consumers Physical product and delivery uncertainty (the consumer cannot be sure of the condition of the product he/she is buying. The delivery time can sometimes be longer than expected) Perishable goods (Electronics devices such as computers need to be handled carefully. If not they might get damaged during shipping and delivery) If a product is damaged, returning the good is difficult and sometimes even impossible. The consumer has no guarantee of getting a refund. The cost of returning the goods (posting) has to be sometimes handled by the consumer. Privacy and security (The payment details of the customer might get stolen over the internet due to lack of security thus leading to fraud) The customer has to go through the products with the limited knowledge he/she has. There are no employees to help guide them into buying exactly what they are looking for.

Executive Summary :: essays research papers

In our business world we have to provide quality atmosphere service to our customers. The purpose for this introduction is to explain how we treat our internal and external customers in order to provide satisfaction. The base of this executive summary will be on where we work at with our current employer or former.   Ã‚  Ã‚  Ã‚  Ã‚  The information collected for this executive summary will be on my last employer. My former employer was Eppies Restaurant. Mainly this small business was in Madera California. Now that we addressed the company, we now can adopt quality principles in theory for my former employer Eppies Restaurant. As I stated in the past, Eppies Restaurant has been open for several years until they closed recently. Since Eppies Restaurant is a food service industry, I can tell you from experience, that it can be very stressful for employees.   Ã‚  Ã‚  Ã‚  Ã‚  We as managers must understand that not just people from the community is our customers, but also our employees are too, and business partners, suppliers etc. For example, we have owners (managers), waitress, busboys, dishwashers, cooks; these were the employees who worked at Eppies Restaurant. Employers have always have choices about how they want their business run, but today managers must be more user friendly. Since business runs a cycle one company relieves on other companies services, this would be an external customer.   Ã‚  Ã‚  Ã‚  Ã‚  Eppies Restaurant had many external customers. For example, we had M& D services they deliver meat and other products. Then we had Rainbow and they deliver bread. We also had a Towel Service they would wash our towels that we use to clean the restaurant. And finally the soda industry and dishwasher industry that supplies their product to any fast food companies. They all provide a service. Eppies Restaurant would buy an extra order for their product and in return they would get a discount. Finally we have our customers who buy our foods. The fast food industry can be very busy especially mothers day. We get anger customers because foods are brought late. The service is bad and seating customers has a big affect on our service to the community. The lesson learned steps in. This also applies for internal employees who work to provide the quality service.

My High School Experience Essay

When people start high school they’re usually so excited. They can’t wait to experience everything that comes with being in high school, I mean who wouldn’t? Everyone says that high school is the best four years of your life. Now that I’m months away from graduating, I can’t say they were my best years but I can say they were my most educational years, of course I wouldn’t say that they weren’t fun because they were. When I say educational, I mean I’ve learned so much about myself and so much about life. I learned what the words family, love, betrayal, law and life meant. All these events changed me, and I’m glad they happened because I wouldn’t have learned all these lessons. My personality hasn’t changed; I’m still a carefree girl, just with a little more wisdom and a lot more strength. I started off school with a horrible attitude because my parents sent me to a different school. They sent me to a school where I knew about two people, I was so angry at my parents that I decided to rebel until they would transfer me to Eastlake. When I went back to Eastlake everything was good again, I made new friends and I even had a boyfriend. My priorities were never really about school or getting good grades, it was always about my friends and my boyfriend. I would ditch on a daily basis just to spend more time with them even if we didn’t really do anything exciting, just as long as I didn’t have to be bored in a classroom. My ditching got so bad it got to the point where my teachers didn’t even know my name, or they thought I transferred out of their class. As a result to all this ditching, I had horrible grades and I was way behind on my credits. I regret ditching because I ruined my chances of going to a university; instead I’m going to a community college. I realize now that I ditched for no reason at all, it was a waste of my time. I look back and think that ditching is just so ridiculous, there really is no point to it unless you want to ruin your future. Remember how I said I learned what the words family, love and betrayal meant? Well, in my situation they sort of all happened together. My freshmen and sophomore year, I had my first real boyfriend. I was completely and totally in love with this guy, he changed me in ways that I’m proud of and ways that I’m not proud of. I revolved my world around him, which wasn’t a good idea. After almost two years of dating, we broke up and it literally shattered my world. During our relationship I became friends with his friends and I even considered one of them my best friends, so when we broke up I didn’t only loose him, I lost all of them as well. It felt so awful to all of a sudden have everything, and then just lose everything in a day. A couple of weeks later, I found out that my best friend was actually dating my ex boyfriend. I couldn’t believe that a person could betray someone like that, especially after everything that she and I went through together. I’m not proud of the events that happened after all of this, and I’m not proud of how I let them change me. The one thing that saved me was my family; they saved me in ways I can’t even explain. They gave me hope and a new life for me that I am extremely grateful for. I’ve learned to be wiser when it comes to picking friends, and choosing who to put my trust in. I also became a stronger person, I don’t let people walk all over me or I don’t let people control my life anymore. The last event is the one that taught me the most about how hard life is, and how life isn’t always fair. My junior year was spent in Tijuana, I would go every weekend to hang out with my cousins and now I have a good life over there. I was never considered a bad kid or a bad influence to other people but everyone goes off course at some point in their life, well mine was spending the night in jail. I could honestly say that I didn’t do anything to deserve being there, except just being at the wrong place with the wrong people. It was really tough to see the disappointment in my parents faces when they saw me in there, it’s probably the worst place for your parents to see you in. I felt helpless because even though I committed no crime, I was still treated as if I did and it was just an awful experience to go through. After I got out, I decided to leave all those friends behind because they didn’t do me any good except get me in trouble. I learned the hard way that people can bring you down, even if you don’t expect it. Throughout my four years of high school I learned to not follow the crowd, even if it may seem extremely cool at the time. I do regret the things I did, but in a way I’m glad for the lessons I could take from them. All of these events made me a stronger person, and I’ve learned what right and wrong is. My parents and I had a rocky four years, I put them through so much disappointment and stress but in the end, I finally became the good daughter. I don’t disrespect them anymore, I care about school, and I’m glad to say that I haven’t disappointed them in a very long time. I think it’s amazing how much a person can grow and transform into something they never thought they would be. I’m looking forward to graduating and proving all the people that looked down on me wrong, it’s going to be an amazing feeling. These four years are only the beginning, they couldn’t have been my best years because my life is not even close to being over, I’m going to learn so many more things and have even better memories.

Invention: History of the Internet and Wheel

From the earliest record of civilization stemming twelve thousand years ago in Kyushu, Japan, mankind has strived to make the quality of life easier, better and more convenient with each generation. Great imagination combined with science, research, skill and patience are the tools used to create remarkable inventions that allow people today to take so much for granted in life. From my point of view, the three inventions that are the most important ones to mankind are the wheel, electricity, and the Internet.The most profound invention of all time is the wheel. Not only does it provide many sources of convenience in life, but it is also essential in the success of several other inventions. Without the wheel, discovering new lands would have been impossible, as explorers needed carriages to carry supplies, people, medicines, and other essential items for journeys. Agriculture would not be anywhere near what it is today without the basic wheel. Planes would not be able to take off or l and without the wheel.People would not be able to commute long distances to and from work. Police cars, fire engines, and ambulances would not be able to get to victims with speed without the wheel. In every aspect of life, the wheel is the one invention that people cannot live without. Long gone are the days where the sun determined when a functional day would start or end. It is the invention of electricity that gives people the opportunity to read books printed in mass copies from a machine at any time of the night and gives everyone freedom to come home to a warm meal.Today, it is routine to wake up to the sound of an alarm, and turn on the coffee maker. With each step taken during the day comes the need to use more electricity. From starting a car to get to one’s destination, and listening to the radio, or watching television, and using computers to write essays such as this one, electricity is the driving force that enables man to accomplish these tasks, which makes ele ctricity one of the greatest inventions of all time.With the invention of the Internet and its implementation in society, the world as we know it has changed drastically in the last fifteen years. The idea of direct communication first introduced by the telephone has far been surpassed with online communication tools such as Skype and Facetime. The convenience of ordering everything imaginable, from groceries, to books, to clothes, to vacation packages, and making dinner reservations all with the click of a button, is a convenience that is only possible because of the Internet.Today, the entire world and answers to all questions are easily accessible and so convenient that society has become as dependent on internet, as they are to electricity and the wheel. From the discussion above, we may safely draw the conclusion that the wheel, electricity and the internet are the most important inventions that shape society. For most, living without these is an impossibility. Not only do the serve as the foundation to other inventions, but they will continue to influence inventions to come.

Middle School vs. High School Essay

One, the closing of one’s grade school years, and the other, a gateway to young adulthood. Middle school and High school, two very important times of a young person’s life, share some similarities and many differences. Middle school, just like its title explains, is the time when students are stuck in the middle of childhood and young adulthood. People start to mature from earlier elementary years, and try to find out who they are. While in the process of trying to fit in, new friend groups are shaped and instead of being one big group of people, circles form and groups are segregated. In addition to more classmates and teachers, responsibilities increase as students take on the load of multiple classes, and now receive grades for their work. Teachers expect them to participate actively in class, and complete their assignments on time. Although it only lasts 3 years, middle school is the critical transitional period when new teachers, new classmates, more classes, and more work are introduced all to prepare you for high school. After 8th grade, people leave the middle school bubble, and advance to the jungle of high school. Not only is the campus physically larger, but class sizes increase, and great expectations come along with it. Although middle school may have seemed like a challenge, high school comes with once again more work and more responsibilities. For students, high school is a sink or swim moment, and some struggle to stay afloat. Some may have trouble focusing in school, but the ideal student is completing their homework on time, studying for their exams, attending practice for their extracurricular activities, and achieving a respectable grade point average, that will all pay off and get them into their dream college. Not only is the work different between the two environments, but so is the amount of freedom students get. In middle school, kids are restrained to a certain curriculum. The schedule they get, is the schedule they get, and nothing is changing. Part of their schedule, lunch, is also a time that is also very different in middle school. All students are required to eat lunch in the same room at the same time, and lunches include a choice between mystery meat, or last week’s hot dogs disguised as soup. Contrary to middle school, in high school, students are granted much more freedom. Students can choose which classes they will take, what teachers they have, what groups or clubs they will participate in, what sports they will play, and much more. Not only can students choose all of their activities, but students also have many options for what they want to eat. High schools often carry popular foods such as subway, burgers, and French fries, and healthy foods such as fruit, and salads. Just in case the school food is not good enough, many high schools often allow upperclassman to leave for lunch to enjoy a meal in their own home, or food from another restaurant. Overall, high school and middle school are both made to prepare students for higher education, but are very different in many aspects. As we all grow older, we can see how we have changed from middle school to high school, and can see the many distinctions between the two.

Case Study Essay Example | Topics and Well Written Essays - 500 words - 18

Case Study - Essay Example As can be seen from the market concentration of the web browser industry it is majorly covered by two players with Microsoft and Mozilla Firefox covering 84.7% market share. The entry and exit barriers are relatively higher and the product is mostly homogenous across all companies without much differentiation. This suggests an oligopolistic nature of the web browser industry. The companies are dependent upon others and shall take other companies actions and counter-moves of other companies wile making decisions (Melvin and Boyes, 2002). The oligopolistic nature of the web browser industry implies that there is a chance that companies might indulge in collusion to stabilize the market position. In such a situation, the role of Competition Commissions become important to stop the formulation of cartels as it may hinder the growth of the market. In the case of web browser industry, Microsoft is bundling the web browser with its operating system, thereby giving less chances for other players to launch their web browser and earn profits. As a result of the skewed market share of the web browser industry, the smaller players in the market have to try hard to gain market share and find innovative ways of doing the same. The Web Browser Industry has performed exceedingly well with the rise in the internet and the world wide web. Over the last few years, Google Chrome has shown significant growth in the market share. The growth in the market share of Chrome has resulted in a drop in the market share of Microsoft web browser. Companies have made new revenue streams such as online marketing. The competition commissions in its decision said that it is necessary for Microsoft to show the browser choice screen. The reason stem from the fact that when the windows is shipped, it is boxed with the internet explorer which roled to many users not making use of other web browser. In order to provide a level playing ground for all the web browser providers, it is necessary

Literary Analysis of Imagery in The Scarlet Ibis Essay

Literary Analysis of Imagery in The Scarlet Ibis - Essay Example The first scene contains a number of imagery, which readers can easily interpret through sensory experience. The visual symbolism in the bleeding tree, the silvery powder and the purple phlox are examples of imagery, which connote the fate facing different characters throughout the story. In addition, Hurst (1) uses olfactory imagery in his presentation of the flowers blooming at the graveyard, which he says produce smell that extends to the length of the cotton plantation. The author’s assertion that the plants rot brown magnolia flowers is rife with imagery of the attractiveness of the graveyard, and the existence of some temporal life. Moreover, the growths of ironweeds which compete with the attractive flowers symbolize the feeling of abandon of the dead. Apart from the existence of the plant imagery, there is auditory imagery in oriole’s beautiful melodies in the elm (Hurst 1). This symbolizes a sense of life and excitement in the story. In addition, the green-draped parlor is rich with visual imagery of attractive vegetation, fair weather, and rich soils, supporting the plants’ and animals’ lives. Doodle in itself is a name that brings out the visual imagery of the small doodle-bug that naturally walks backwards. This implies the character is one who would never tire of going the opposite direction on social issues affecting him and the immediate environment where he stays (Hurst 2). Further, Hurst’s use of a deafening thunder and mournful sound symbolizes the existence of powers, which are beyond the existence of animals and plants. The latter auditory imagery symbolizes mortal nature of living things on earth, even when they are seen as blossoming and death is seemingly not in sight. The two forms of imagery are complimented by the visual imagery in the green-draped parlor, which is by its description